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bafffalliehavathan
Jun 17, 20222 min read

Es-1649 E-5405 1000 Driver De Rede







Es-1649 E-5405 1000 Driver De Rede es-1649 e-5405 1000 driver de redeIntroduction {#sec1} ============ Lichen planus pigmentosus (LPP) is an inflammatory dermatosis characterized by presence of hyperpigmented lesions of the skin that do not infiltrate dermis or subcutaneous tissue.[@bib1] On the basis of its clinical and histopathological features, LPP is considered a variant of lichen planus.[@bib1], [@bib2], [@bib3] LPP is often refractory to treatment with topical corticosteroids and phototherapy[@bib1], [@bib2] despite its reported association with lichen planus.[@bib1], [@bib4], [@bib5] Dapsone is an old drug discovered by Selman Waksman and Albert H. Mazur in the late 1950s and introduced to clinical practice in 1960.[@bib6] It was developed as the best available drug for leprosy at the time.[@bib6] It has since been used in dermatology for immunosuppression, due to its ability to inhibit in vitro T-cell activation by blocking thiopurine methyltransferase, a key enzyme in the synthesis of methylated nucleotides.[@bib7] Derivatives of dapsone can be also used as a chemopreventive agent in combination with other drugs for cancer treatment.[@bib8] Case report {#sec2} =========== A 52-year-old woman presented with a history of pruritic papules and plaques in the neck for 3 years ([Fig 1](#fig1){ref-type="fig"}). Examination revealed hyperpigmented macules and papules of 25 years duration on the neck and scapular region extending to the supraclavicular area. There was no pustular eruption or mucosal involvement ([Fig 1](#fig1){ref-type="fig"}, *A* and *B*). Biopsy specimens from papular lesions showed hyperkeratosis and acanthosis with foci of suprabasal clefts (SBC) and small focal lymphocytic infiltrate ([Fig 2](#fig2){ref-type="fig"}, *A* and *B*). Examination with direct immunofluorescence (DIF) of 1:26 PM -|~@. 0 |-CDER :D,,.,,  ...,,,,,,..,...|-|.....|.......|.....|  .....|  .... |.....|.......|....|.. |.. |..|  .... |.... |.... |....|  ....|....|..|..|..|....|....|. |. es-1649  . 1000 ..+........|......|.......|.......|..... |...... |......|......|.....|.... |....|.....|  ....|.....|. |. |..|....|  .... |.... |.....|  ....|.....|......|......| es-1649 es-1649 es-1649  | 00.00.00.00.00.00. 00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00. f30f4ceada


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